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. 2024 Jun 7;20(6):e1012131. doi: 10.1371/journal.pcbi.1012131

Fig 4. Antibody profile of protected and non-protected vaccinees and the control group against informative cell-surface Pf-specific antigens.

Fig 4

Informative Pf-specific antigens against pre-selected Pf-specific cell-surface antigens were evaluated at post-immunisation and pre-CHMI. Pf-specific antigens identified to be important by ESPY evaluation showed either a high antibody signal intensity in protected vaccinees or unprotected vaccinees and controls. The top 50 Pf-specific antigens with the highest ESPY values are shown (A) at post-immunization and (B) at pre-CHMI. The heatmap plot shows the antibody signal intensity, while the bars on the right side of each figure show the importance and effect of each feature based on the ESPY value. ESPY values of Pf-specific antigens that were evaluated to have a positive effect on the protection status classification are colored in red, while blue-colored bars represent antigens that have a negative effect.