Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Mar 8;31(6):925–938. doi: 10.1038/s41594-024-01246-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — a, Three mutations associated with RSS or XLID highlighted within the context of the Commander complex structure. b, Effect of A830T mutation on VPS35L in BioID–MS. All PPIs passing HCI criteria to either wild-type VPS35L or VPS35L(A830T) are plotted for both constructs, with HCIs indicated using a black outline and non-HCIs with a light blue outline. Node color corresponds to the bait normalized abundance of the average spectral count for each prey, and node radius to its relative abundance across all baits determined by ProHits-Viz. c, Composite model of the Commander complex, indicating putative interaction interfaces with TPGC. d, Rotated view of the model in c, with putative interaction interface of the WASH complex indicated.