Fig. 2.

Treatment response and survival outcomes. a Waterfall plot of the best percentage changes for the sum of target lesion diameters for patients received at least one time of radiographic evaluation. *This patient had a >20% increase in the sum of diameter, but with absolute increase <5 mm, per the IRRC and, therefore, stable disease (SD) was documented instead of progressive disease (PD). ^The indicated lesion in this patient is lymph node. b Swimmer plots of time to tumor response (months) of individual patients with metastatic nasopharyngeal carcinoma as assessed by the independent radiological review committee (IRCC) according to the Response Evaluation Criteria in Solid Tumors (RECIST), version 1.1. Each swim lane represents one patient in the full-analysis set (FAS) per IRRC. Patient responses are color coded. CR complete response, NE not evaluable, PD progressive disease, PR partial response, SD stable disease. Kaplan–Meier-estimated progression-free survival (PFS) curves (c) and overall survival (OS) curves (d) of NPC patients in the FAS per IRRC