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. 2024 Jun 18;14:14092. doi: 10.1038/s41598-024-64126-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of β-catenin and PD-L1 following administration of PAK4 inhibitor in oral squamous cell carcinoma (OSCC) tumour-bearing mice. In OSCC tumour-bearing mice administered the PAK4 inhibitor, PF-3758309, the expression of β-catenin in tumour cells and of PD-L1 on the surface of tumour cells was analysed using flow cytometry. Representative histograms and bar graph of overall results are shown (n = 4/group); p < 0.05, control versus PF-3758309. Numbers in each panel indicate the mean fluorescence intensity of each molecule in control (upper value) and PAK4 inhibitor-treated (lower value) mice.