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. 2024 Jun 18;14:14092. doi: 10.1038/s41598-024-64126-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Phenotypic alteration of tumour-infiltrated dendritic cells (DCs) following administration of PAK4 inhibitor in oral squamous cell carcinoma (OSCC) tumour-bearing mice. The phenotypic profiles of DCs in OSCC tumour-bearing mice after administration of the PAK4 inhibitor were analysed. Cells were harvested from the tumours of control or PAK4 inhibitor-treated mice, and the cell-surface expression of various lymphocyte co-stimulatory molecules on CD11c⁺CD103⁻ and CD11c⁺CD103⁺ cells was determined using flow cytometry. Representative histograms are shown (n = 4/group). Numbers in each panel indicate the mean fluorescence intensity of each molecule in control (upper value) and PAK4 inhibitor-treated (lower value) mice.