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. 2024 Jun 18;15:5216. doi: 10.1038/s41467-024-49599-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Cryo-EM density map corresponding to the three conformations. The top panel shows the side view and the lower panel shows the bottom view of the structures. One protomer in each of the three structures is colored either sky blue (Closed), lime green (Intermediate), or salmon (Open). Putative lipid densities were only observed in the Closed conformation and are colored orange. b-d, Side view of pairwise superposition of the various protomers: b the Closed and Intermediate state; c the Intermediate and Open state; d the Closed and Open state.