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. 2024 Jun 18;7:741. doi: 10.1038/s42003-024-06416-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Boxplots of (a) Response threshold a and (b) drift rate v of each group. c Schematic representation of model parameters of each group. d Relationship between the drift rate (y-axis) and time to predicted age-at-onset (x-axis). e Relationship between the drift rate (y-axis) and the response threshold (x-axis). Points represent individual values, lines and shades around them represent the linear fit and the confidence interval, respectively. Controls are represented in grey (n = 45), premanifest participants (preHDs) in blue (n = 20, n = 7 far, n = 9 middle, n = 4 close to onset), and early-stage Huntington’s disease patients (earlyHDs) in red (n = 28). In boxplots in (a), (b), and (d), the middle hinge corresponds to the median, the lower and upper hinges correspond respectively to the first and third quartiles.