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. 2024 Jun 18;7:741. doi: 10.1038/s42003-024-06416-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Hippocampus (yellow). X is MNI coordinate. A anterior, P posterior. b Cortical maps of significant clusters with significant relationship between the cortical thickness and the drift rate. Light grey represents gyrus and dark grey represents sulcus. Yellow: left superior parietal cluster (152.71 mm2, MNI coordinates: [–34, –55, 59]); Orange: right superior temporal cluster (112.72 mm2, MNI coordinates: [63, –16, –1]). c Relationship between the hippocampus volume normalized to the total intracranial volume (tiv) (x-axis) and the drift rate (y-axis). For representational purposes, the x-axis is multiplied by 100. d Relationship between the mean cortical thickness in the yellow cluster (panel b) (x-axis) and the drift rate (y-axis). e Relationship between the mean cortical thickness in the orange cluster (b) (x-axis) and the drift rate (y-axis). f Boxplots of the normalized hippocampus volume. g Boxplots of the mean cortical thickness in the yellow cluster. h Boxplots of the mean cortical thickness in the orange cluster. *p < 0.05, **p < 0.01, ***p < 0.001. Imaging controls are represented in grey (n = 30), premanifest participants (preHDs) in blue (n = 20, n = 7 far, n = 9 middle, n = 4 close to onset), and early-stage Huntington’s disease patients (earlyHDs) in red (n = 28). In c, d, and e, points represent individual values, whereas lines and shades around them represent the linear fit and the confidence interval, respectively.