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. 2024 Jun 18;7:737. doi: 10.1038/s42003-024-06426-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Molecular subtyping of ROIs using the consensusMIBC R package. Left, Heatmap showing enrichment scores for each subtype in tumour, stroma, and immune infiltrated ROIs. Assigned cell types are shown in the top panel. Some ROIs were not enriched for any signature and were assigned an undefined subtype. Right, stacked barplot showing distribution of each subtype in tumour, stroma, and immune infiltrate ROIs. b Comparison of molecular subtypes assigned to tumour ROIs and subtypes assigned to the same tumours using conventional bulk sequencing (overlap between datasets n = 28 ROIs, 19 donors). c Volcano plots showing differentially expressed genes between basal (n = 15), luminal (n = 22), or undefined (n = 9) tumour ROIs and all other tumour ROIs. d Violin plots showing expression of KRT5, GATA3 and GOLGA6A in tumour ROIs. e IPA enriched pathways in basal, luminal, and undefined subtype differentially expressed genes.