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. 2024 Jun 18;15:5191. doi: 10.1038/s41467-024-49050-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Unsupervised WNN clustering and UMAP projection of 42,067 CD4⁺CD69⁺CD154⁺ T cells measured by CITE-Seq reveals 11 distinct clusters. b Graph showing select genes used in cluster annotation. The percentage of cells expressing select genes (size of circle) and the average expression of each gene (color of circle) by cluster is shown for the CD4⁺CD69⁺CD154⁺ T cells measured by CITE-Seq. c Ridge plot of the normalized antibody-derived tagged (ADT) surface marker expression on the CD4⁺ T cells by cluster. d Heatmap showing average gene expression per participant of the top 10 genes that distinguish the different clusters from each other.