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. 2024 Jun 18;15:5222. doi: 10.1038/s41467-024-49299-6

Fig. 4. TBI induces cell population-specific changes in gene expression in NSCs and NSC-derived cells in the DG.

Fig. 4

Heatmaps showing expression of individually upregulated (a) and downregulated (b) genes across NSCs and NSC-derived cell populations. Color bars indicate the relative intensity of expression, indicated as ln fold change in TBI vs. Control groups; SCT normalized data are compared. Violin plots showing changes in Ppp1r14b expression induced by TBI in RG-like cells, ***P = 5 × 10−4 (c), NSC-stage 2 cells, ***P = 8.28 × 10−7 (d) astrocytic A-stage 3 cells, ***P = 4.93 × 10−5 (e), and neurogenic N-stage 1, ***P = 3.21 × 10−15 (f), N-stage 2, ***P = 8.59 × 10−16 (g), N-stage 3, ***P = 1.38 × 10−13 (h) and N-stage 4 cells, ***P = 6.44 × 10−12 (i), two-sided MAST test with Bonferroni post hoc test on SCT normalized data. Source data are provided at https://zenodo.org/records/10829090/files/AstrocyticAndNeuronalLineage_10x.RData?download=1.