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. 2023 Nov 23;4(3):20230025. doi: 10.1002/EXP.20230025

FIGURE 2.

FIGURE 2

Designs of pH‐responsive nanoparticles for protein delivery. (A) The block copolymers composed of PEG and [P(CPTMA‐co‐PEMA)] can form polymersomes and load GOD into the interior aqueous chambers. The pH‐sensitive PEMA group is utilized to increase the permeability of the polymersome membranes, triggering hydrogen peroxide generation under the catalysis of GOD and subsequently releasing CPT from the polymeric prodrugs in lung cancer tissues. Reproduced with permission.[ 22 ] Copyright 2017, American Chemical Society. (B) N‐dibutylaminoethyl‐modified PAMAM can encapsulate cargo proteins and facilitate endosomal escape. Reproduced with permission.[ 24 ] Copyright 2021, Chinese Chemical Society. (C) Polyphenol nanoparticles can deliver anti‐TNF‐α antibodies to the inflamed colon tissues for the treatment of colitis via oral administration. Reproduced with permission.[ 28 ] Copyright 2020, Ivyspring International Publisher.