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. 2023 Nov 23;4(3):20230025. doi: 10.1002/EXP.20230025

FIGURE 5.

FIGURE 5

Designs of ultrasound or magnetic field‐responsive protein delivery systems. (A) ZIF‐8 nanoparticles can encapsulate sonosensitizer HMME and CRISPR/Cas9. Under ultrasound application, this system will produce ROS and release CRISPR/Cas9 in the cytoplasm for gene therapy. Reproduced with permission.[ 60 ] Copyright 2022, Springer Nature. (B) Recombinant protein nanoparticles are loaded with magnetic core and grafted with PEG chains. After microinjection, cytosolic proteins or organelle‐anchored proteins that are fused to anti‐EGFP antibodies will be rapidly targeted by nanoparticles. The magnetic tip can help either control the localization of cytosolic proteins or manipulate organelle functions. Reproduced with permission.[ 64 ] Copyright 2017, Wiley‐VCH.