Intervention and comparator intervention	Duration of follow‐up	Participating population	Study period [year to year]	Country	Setting	Ethnic groups [%]	Duration of Graves' disease
Barczynski 2012	I: total thyroidectomy	5 years	Adults diagnosed with Graves' disease and mild active ophthalmopathy	2000 to 2004	Poland	Teaching hospital	‐	< 24 months
	C: bilateral subtotal thyroidectomy							< 24 months
Witte 2000	I: total thyroidectomy	6 months	Participants with clinically or biochemically proven Graves' disease	1993 to 1995	Germany	Teaching hospital	‐	2‐300 months
	C1: bilateral subtotal thyroidectomy							2‐300 months
	C2: Dunhill procedure							2‐300 months
Jarhult 2005	I: total thyroidectomy	3 years	Participants with Graves' disease and moderate to severe ophthalmopathy	‐	Sweden	University/county hospitals	‐	‐
	C: subtotal thyroidectomy
Chi 2005	I: bilateral subtotal thyroidectomy	26.4 (SD 1.1) months	Participants undergoing subtotal thyroidectomy for Graves' hyperthyroidism	1998 to 2002	Taiwan	Teaching hospital	‐	‐
	C: Dunhill procedure
Muller 2001	I: bilateral subtotal thyroidectomy	6 years	Diagnosed with Graves' disease if participants had hyperthyroidism and had ophthalmopathy or TSH‐R antibodies, or based on US scan	1988 to 1992	Germany	Tertiary referral centre	‐	‐
	C: Dunhill procedure
‐ denotes not reported C: comparator; I: intervention; SD: standard deviation; TSH‐R: thyroid‐stimulating hormone receptor; US: ultrasound