Intervention and comparator intervention	Sex [female %]	Age [mean years (CI/SD/range)]	Comedications/Cointerventions	Comorbidities
Barczynski 2012	I: total thyroidectomy	89	46.2 (CI 43.5 to 48.9)	Antithyroid drugs/beta blockers	‐
	C: bilateral subtotal thyroidectomy	89	45.5 (CI 43.1 to 47.9)
Witte 2000	I: total thyroidectomy	82	38 (19 to 68)	Antithyroid drugs/beta blockers (40%), thyroid hormone substitution (40.7%)	‐
	C1: bilateral subtotal thyroidectomy	86	35.5 (12 to 73)
	C2: Dunhill procedure	82	41 (17 to 66)
Jarhult 2005	I: total thyroidectomy	95	44 (21 to 62)	Antithyroid drugs for at least 3 months preoperatively Postoperative thyroxine supplementation 5 participants in each group received cortisone to decrease the activity of the EO	‐
	C: subtotal thyroidectomy	86	42 (24 to 69)
Chi 2005	I: bilateral subtotal thyroidectomy	84	33.3 (SD 0.73)	Propylthiouracil/methimazole	‐
	C: Dunhill procedure	87	34.5 (SD 0.93)
Muller 2001	I: bilateral subtotal thyroidectomy	‐	30.8 (14 to 78)	Antithyroid medication	‐
	C: Dunhill procedure	‐	30.8 (14 to 78)
‐ denotes not reported C: comparator; CI: confidence interval; EO: endocrine ophthalmopathy; I: intervention; SD: standard deviation