Figure 3.

Representative photomicrographs from immunohistopathological analyses of renal biopsy tissue sections, showing a diffuse population of large, atypical cells with irregular nuclei, prominent nucleoli, and increased mitotic activity (A and B: Hematoxylin and Eosin staining). Strong and diffuse immunostaining for CD20 in atypical infiltrating lymphocytes (C). Only occasional immunostaining for CD3 and CD5 in non-neoplastic cells is shown (D, E). No immunoreactivity of neoplastic cells to CD10 and CD68 is observed (F, G). A few CD138 plasma cells are observed (H). No significant IgG4-positive cells among the IgG-positive cells are shown (I, J). No significant differences are observed between kappa and lambda light chains (K, L). A: high-power field; B-L: low-power field.