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. 2024 Jun 20;14(6):e1740. doi: 10.1002/ctm2.1740

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© 2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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miR‐1203‐related circles promote the progression of papillary thyroid carcinoma (PTC). (A) Heatmap showing extrachromosomal circular DNA (eccDNA) containing full‐length miRNA genes abundance between the PTC and nodular thyroid goitre (NOD) groups. (B) Validation of miRNA1203‐related eccDNAs by agarose gel electrophoresis. (C) Synthesis of miRNA1203‐eccDNAs by the Ligase‐Assisted Mini‐circle Accumulation (LAMA) method. (D, E) Gene ontology (GO), KEGG and gene set enrichment analysis (GSEA) pathway analysis of miRNA1203‐eccDNA biological functions.