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. 2024 Jun 20;14(6):e1740. doi: 10.1002/ctm2.1740

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© 2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Characteristics of human extrachromosomal circular DNA (eccDNA) in tissue and plasma of human papillary thyroid carcinoma (PTC) cell xenografts mice. (A) Summary of the number of eccDNA of mouse or human origins detected in xenograft mouse plasma. (B) GC content distribution of eccDNA and their up‐ and down‐stream regions with equal length in tissue and plasma. (C, D) Motif patterns of eccDNA junction sites and chromosomes distribution of PTC cell line xenograft mouse tissue and plasma.