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. 2024 Feb 2;29(5):1440–1449. doi: 10.1038/s41380-024-02422-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Induced neurons (Ins) derived from tissue biopsies from SZ and HC subjects. The iNs were generated by direct reprogramming of fibroblasts obtained from SZ and HC tissue biopsies. Neurons were subjected to KCl (50 mM) stimulation of secretion and the media was collected for neuropeptidomics analysis achieved by nano-LC-MS/MS tandem mass spectrometry and bioinformatics using PEAKS and NeuroPedia for identification and quantitation of neuropeptides. b SZ and HC biopsy samples. Individual SZ and HC biopsy samples are listed by condition of SZ or HC, age, and gender. The sample sizes were selected based on power analysis to characterize neuropeptide identities and quantities with significance. Note that the predicted effect was not known at the beginning of this project, and effects of only in SZ or only in HC were observed with SZ (n = 7) and HC (n = 6) numbers of patient-derived cell lines in this study.