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. 2024 Apr 8;28(7):599–607. doi: 10.1007/s10157-024-02502-w

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© The Authors 2024, corrected publication 2024

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Fig. 3 — Sirt1 mediates organelle protection. Proximal tubules require high amounts of ATP to reabsorb the necessary substances in the urine. Therefore, proximal tubules contain abundant mitochondria and peroxisomes. Sirt1 reportedly activates mitochondrial and peroxisomal functions. Thus, Sirt1 is presumed to play an important role in the proximal tubules