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. 2024 Apr 8;28(7):599–607. doi: 10.1007/s10157-024-02502-w

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© The Authors 2024, corrected publication 2024

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Fig. 5 — Schema depicting proximal tubule–podocyte communication. High glucose exposure primarily downregulates proximal tubular Sirt1 levels. This reduces NMN and podocyte Sirt1 levels, accompanied by Claudin-1 induction and albuminuria