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. 2024 Apr 8;28(7):599–607. doi: 10.1007/s10157-024-02502-w

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© The Authors 2024, corrected publication 2024

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Fig. 6 — Epigenetic regulation of claudin-1 expression in podocytes by Sirt1. Under normal glucose conditions, retained Sirt1 deacetylates H3 and H4 histones, resulting in H3K9 histone methylation and Dnmt1 activation. H3K9, histone H3 Lys⁹; HMT, histone methyltransferases; ME, methyl-; DNMT, DNA methyltransferases; CG, CpG islands