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. 2024 Apr 8;28(7):599–607. doi: 10.1007/s10157-024-02502-w

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© The Authors 2024, corrected publication 2024

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Fig. 7 — Scheme depicting the mechanism of Nampt-related type-IV collagen deposition in DN. In DN, a decrease in Nampt suppresses Sirt6 levels. Augmented acetylation of H3K9 mediated by downregulated Sirt6 escalates TIMP-1 expression because RelA attaches to the RelA-binding site in the promoter of TIMP-1. Elevation of TIMP-1 induces type-IV collagen production