TABLE 1.
Basic characteristics of included trials and subjects.
| References | Sample size (T/C) | Age (years) | Intervention | Control | Treatment duration | Follow-up duration | Outcome measures |
|---|---|---|---|---|---|---|---|
| Tong QL et al., 2023 | 126 (63/63) | T: 29.14 ± 5.23 | CHM (Fufang Xuanju capsules) | Blank Control | CHM:1.26 g, tid, discontinue during menstruation, 4 weeks/course * 3 courses | 12 months | ①②③⑤ |
| C: 29.37 ± 6.02 | |||||||
| Wu L et al., 2021 | 106 (53/53) | T: 34.32 ± 2.35 | CHM (Cinnamon Twig and Poria pills) + Leuprorelin | Leuprorelin | CHM:1.35 g, bid, discontinue during menstruation, 4 weeks/course * 6 courses | 6 months | ②③ |
| C: 34.96 ± 2.15 | Leuprorelin: Once every 4 weeks * 6 courses | ||||||
| Zhao XJ et al., 2020 | 116 (58/58) | T: 29.41 ± 5.27 | CHM (Yishen Shugan decoction) +Triptorelin | Triptorelin | CHM:1 dose/d (100 mL, tid), discontinue during menstruation, 4 weeks/course * 6 courses | 6 months | ①②③④⑤ |
| C: 29.45 ± 5.21 | Triptorelin: Once every 4 weeks * 6 courses | ||||||
| Liu X 2020 | 66 (33/33) | T: 31.53 ± 6.09 | CHM (Huayu Xiaozheng decoction) + Goserelin | Goserelin | CHM:1 dose/d (200 mL, bid), discontinue during menstruation, 14 days/course * 3 courses | 7 months | ①④⑤⑥ |
| C: 32.07 ± 4.81 | Goserelin: Once every 28 days * 3 courses | ||||||
| Qiu YF et al., 2019 | 68 (34/34) | T: 28.25 ± 6.12 | CHM (Wenshen Xiaozheng decoction) + Triptorelin | Triptorelin | CHM:1 dose/d (150 mL, bid), start on Day 5 of Menstrual Cycle, 14 days/course * 3 courses | 24 months | ①⑤⑥ |
| C: 28.19 ± 6.04 | Triptorelin: Once every 28 days * 6 courses | ||||||
| Wang L et al., 2019 | 116 (58/58) | T: 32.15 ± 3.18 | CHM (Xiaojin capsules) +Leuprorelin | Leuprorelin | CHM: 1.5 g, bid, 4 weeks/course * 6 courses | 12 months | ①②⑥ |
| C: 33.21 ± 3.68 | Leuprorelin: Once every 4 weeks * 6 courses | ||||||
| Song HP et al., 2019 | 160 (80/80) | T: 37.12 ± 2.59 | CHM (Kuntai capsules) + Leuprorelin | Leuprorelin | CHM: 2 g, tid, 28 days/course * 3 courses | 4 months | ①③ |
| C: 36.25 ± 3.72 | Leuprorelin: Once every 28days * 3 courses | ||||||
| Lu YH et al., 2019 | 86 (43/43) | T: 29.17 ± 3.28 | CHM (Guizhi Fuling capsules) + Gestrinone | Gestrinone | CHM: 0.93 g, tid, 4 weeks/course * 6 courses | 6 months | ②④⑥ |
| C: 28.76 ± 3.92 | Gestrinone: 2.5 mg, qd, twice a week, 4 weeks/course * 6 courses | ||||||
| Hu YY et al., 2018 | 90 (45/45) | T: 30.9 ± 5.54 | CHM (Dan’e Fukang decocted extract) + Triptorelin | Triptorelin | CHM: 15 g, bid, start orally on Day 10 prior to menstruation, 14 days/course * 3 courses | 6 months | ①②③④⑥ |
| C: 30.20 ± 6.12 | Triptorelin: Once every 28days * 3 courses | ||||||
| Chen M et al., 2018 | 100 (50/50) | T: 31.6 ± 4.72 | CHM (Neiyi decoction) + Triptorelin | Triptorelin | CHM: 1 dose/d (100 mL, bid), discontinue during menstruation, 4 weeks/course * 6 courses | 9 months | ② |
| C: 30.90 ± 5.01 | Triptorelin: Once every 4 weeks * 6 courses | ||||||
| Zhou Q et al., 2016 | 106 (53/53) | T: 31.94 ± 2.80 | CHM (Fuzheng Xiaoyi decoction) + Goserelin | Goserelin | CHM: 1 dose/d (100 mL, bid), 4 weeks/course * 3 courses | 36 months | ①②④⑥ |
| C: 32.64 ± 2.47 | Goserelin: Once every 4 weeks * 6 courses | ||||||
| Xing LM 2016 | 72 (36/36) | T: 29.64 ± 4.91 | CHM (Empirical formula) + Mifepristone | Mifepristone | CHM: 1 dose/d (100 mL, bid), * 3 months | 6 months | ①③④⑥ |
| C: 30.56 ± 5.85 | Mifepristone: 10 mg, qd, * 3 months | ||||||
| Han B 2016 | 60 (30/30) | T: 30.35 ± 5.40 | CHM (Turtle Shell decocted pills) + Leuprorelin | Leuprorelin | CHM: 3 g, tid, discontinue during menstruation, 28 days/course * 6 courses | 6 months | ①③④⑥ |
| C: 28.90 ± 5.49 | Leuprorelin: Once every 28days * 6 courses | ||||||
| Du X 2015 | 120 (60/60) | T: 31.72 ± 6.57 | CHM (Neiyi decoction) + Triptorelin | Triptorelin | CHM:1 dose/d (200 mL, bid), start on Day 5 of Menstrual Cycle, 4 weeks/course * 6 courses | 6 months | ②④ |
| C: 33.76 ± 5.73 | Triptorelin: Once every 4 weeks * 6 courses | ||||||
| Chen LQ et al., 2015 | 48 (24/24) | T: 28.44 ± 2.37 | CHM (Xuefu Zhuyu capsules) + Triptorelin | Triptorelin | CHM: 2.4 g, bid, 30 days/course * 3courses | 3 months | ①②③ |
| C: 27.49 ± 1.95 | Triptorelin: Once every 28days * 5 courses | ||||||
| Chen JJ 2015 | 72 (36/36) | T: 30.17 ± 4.08 | CHM (Bushen Huayu decoction) + Mifepristone | Mifepristone | CHM: 1 dose/d (100 mL, bid), take for 1 week, then discontinue for 1 week, 4 weeks/course * 3 courses | 6 months | ①③④⑥ |
| C: 29.79 ± 4.15 | Mifepristone: 10 mg, qd, 4 weeks/course * 3 courses | ||||||
| Dou N 2015 | 70 (35/35) | T: 26.12 ± 4.21 | CHM (Danbie capsules) | Gestrinone | CHM: 1.9 g, tid, discontinue during menstruation, 28 days/course * 6courses | 12 months | ①②④⑥ |
| C: 28.72 ± 6.14 | Gestrinone: 2.5 mg, qd, twice a week, 4 weeks/course * 6 courses | ||||||
| Li S 2014 | 60 (30/30) | T: 29.4 ± 5.30 | CHM (Empirical formula) | Triptorelin | CHM: 1.5 dose/d (100 mL, bid), 10 days/course * 3 courses | 12 months | ①②⑤ |
| C: 28.9 ± 5.41 | Triptorelin: Once every 28 days * 3 courses | ||||||
| Zhou D et al., 2013 | 120 (60/60) | T: 34.1 ± 1.8 | CHM (Empirical formula) + Mifepristone | Mifepristone | CHM: 1 dose/d (100 mL, qd), 4 weeks/course * 6 courses | 6 months | ①②⑥ |
| C: 34.5 ± 1.1 | Mifepristone: 12.5 mg, qd, 4 weeks/course * 6 courses | ||||||
| Zhang XN 2012 | 60 (30/30) | T: 29.70 ± 4.23 | CHM (Muda Tang granules) | Gestrinone | CHM: 2 sachets, bid, discontinue during menstruation, 4 weeks/course * 3 courses | 6 months | ①③④⑥ |
| C: 29.87 ± 4.43 | Gestrinone: 2.5 mg, qd, twice a week, 4 weeks/course * 3 courses | ||||||
| Ding XQ et al., 2012 | 56 (27/29) | T: 35.84 | CHM (Empirical formula) | Gestrinone | CHM: 1 dose/d (100 mL, tid), discontinue during menstruation, 4 weeks/course * 3 courses | 36 months | ②⑤⑥ |
| C: 34.54 | Gestrinone: 2.5 mg, qd, twice a week, 4 weeks/course * 3 courses | ||||||
| Ma L et al., 2011 | 60 (30/30) | T: 31.7 ± 4.79 | CHM (Xiaojie An capsules) + Gestrinone | Gestrinone | CHM: 0.76 g, tid, 8 weeks/course * 3courses | 36 months | 1 ② |
| C: 31.7 ± 4.79 | Gestrinone: 2.5 mg, qd, twice a week, 8 weeks/course * 3 courses |
AbbreviationC: control; CHM: chinese herbal medicine; T: treatment; ‘bid’ (bis in die) means twice a day; ‘qd’ (quaque die) means once a day; ‘tid’ (ter in die) means three times a day. ①: Recurrence rate; ②: Total clinical efficacy rate; ③: Visual analog scale score; ④: Serum level of CA125; ⑤: Pregnancy rate; ⑥: Adverse events.