TABLE 2.
Pharmacokinetic parameters of five primary constituents of Danshen-Shanzha Formula (DSF) after oral administration of 8.4 g/kg DSF or single herb extract (6 g/kg for Danshen extract, 2.4 g/kg for Shanzha extract) in rats.
| Constituents | Oral source | Contents (mg/g) | Tmax (h) | Cmax (mg/L) | AUC0-t (mg·h/L) | MRT0–t (h) | T1/2 (h) |
|---|---|---|---|---|---|---|---|
| Danshensu | DSF | 1.2 | 0.5 | 1.14 ± 5.8 | 3.65 ± 0.42 | 2.98 ± 0.15 | 2.85 ± 1.2 |
| Danshen | 1.2 | 0.75 | 1.87 ± 0.17 | 4.44 ± 0.66 | 2.76 ± 0.10 | 3.00 ± 8.8 | |
| Rosmarinic acid | DSF | 2.6 | 0.5 | 1.50 ± 0.44 | 2.09 ± 0.39 | 2.50 ± 0.44 | 7.52 ± 4.4 |
| Danshen | 2.6 | 0.33 | 3.88 ± 0.41 | 4.25 ± 0.78 | 1.98 ± 0.12 | 4.34 ± 9.0 | |
| Lithospermic acid | DSF | 5.9 | 0.5 | 3.91 ± 0.41 | 6.49 ± 0.88 | 3.27 ± 0.50 | 3.78 ± 3.8 |
| Danshen | 5.9 | 1.0 | 10.0 ± 0.89 | 27.3 ± 3.0 | 2.93 ± 0.22 | 1.60 ± 0.67 | |
| Salvianolic acid B | DSF | 48.0 | 0.5 | 13.7 ± 0.88 | 38.2 ± 3.0 | 2.85 ± 0.13 | 1.94 ± 2.1 |
| Danshen | 48.0 | 1.5 | 13.2 ± 1.7 | 56.5 ± 6.52 | 3.78 ± 0.19 | 2.50 ± 0.45 | |
| Hyperoside | DSF | 3.0 | 0.75 | 1.93 ± 0.39 | 3.84 ± 0.61 | 2.68 ± 0.16 | 7.0 ± 0.67 |
| Shanzha | 3.0 | 0.5 | 3.27 ± 0.48 | 5.24 ± 0.79 | 2.22 ± 0.20 | 5.35 ± 3.0 |
The data of the contents and pharmacokinetic parameters for the five constituents of DSF, were compiled according to Liu et al.’s study (Liu et al., 2014).