FIGURE 3.

The role of PKM2 in kidney. In tubular epithelial cell, podocyte, fibroblast, macrophage and T cell, PKM2 participate in kidney disease and treatment. Drp-1, dynamin-related protein-1; ERK, extracellular regulated protein kinase; HIF-1α, hypoxia inducible factor-1; HSP90, heat shock protein 90; ICAM-1, intercellular cell adhesion molecule-1; IFN-γ, interferon gamma; IL-17A, interleukin-17A; MYH9, myosin heavy chain 9; NF-κB, nuclear factor kappa-B; NLPR3, NOD-like receptor thermal protein domain associated protein 3; PCNA, proliferating cell nuclear antigen; STAT3, signal transducer and activator of transcription 3; TNF-α, tumor necrosis factor-α; USP25, ubiquitin specific peptidase 25; WT-1, Wilm’s tumor-1.