Table 2.
Costs and benefits of Wolbachia deployments in seven Brazilian cities over 5-, 10- and 20-year horizon.
| City | Costs (per 1000 people) |
Cost difference (per 1000 people) | Dengue casesa |
Dengue cases averted | DALY averted (per 1000 people) | ICER | NMB | ||
|---|---|---|---|---|---|---|---|---|---|
| Without Wolbachia | With Wolbachia | Without Wolbachia | With Wolbachia | ||||||
| 5 years horizon | |||||||||
| Manaus | R$ 9,321,291.94 | R$ 9,086,340.22 | -R$ 234,951.71 | 27,107 | 6430 | 20,677 | 0.53 | Dominance | R$ 298.61 |
| São Paulo | R$ 11,674,360.94 | R$ 11,401,176.00 | -R$ 273,184.94 | 103,141 | 24,638 | 78,503 | 1.78 | Dominance | R$ 486.42 |
| Fortaleza | R$ 8,499,011.86 | R$ 8,007,715.25 | -R$ 491,296.61 | 79,985 | 19,781 | 60,204 | 1.33 | Dominance | R$ 651.36 |
| Niteroi | R$ 9,295,178.36 | R$ 8,324,805.54 | -R$ 970,372.82 | 21,403 | 5141 | 16,262 | 7.03 | Dominance | R$ 1813.86 |
| Belo Horizonte | R$ 11,131,092.17 | R$ 10,717,806.68 | -R$ 413,285.49 | 195,659 | 47,966 | 147,692 | 1.75 | Dominance | R$ 622.70 |
| Campo Grande | R$ 12,528,204.37 | R$ 10,896,787.72 | -R$ 1,631,416.65 | 60,574 | 14,836 | 45,738 | 2.17 | Dominance | R$ 1892.11 |
| Goiania | R$ 11,674,360.94 | R$ 11,401,176.00 | -R$ 273,184.94 | 167,060 | 46,942 | 120,119 | 6.66 | Dominance | R$ 1072.11 |
| Overall (mean) | R$ 10,589,071.51 | R$ 9,976,543.92 | -R$ 612,527.59 | 93,561 | 23,676 | 69,885 | 3.04 | Dominance | R$ 976.74 |
| 10 years horizon | |||||||||
| Manaus | R$ 18,321,062.87 | R$ 18,017,601.69 | -R$ 303,461.19 | 36,492 | 8643 | 27,849 | 0.62 | Dominance | R$ 377.26 |
| São Paulo | R$ 22,621,130.00 | R$ 22,290,670.00 | -R$ 330,460.00 | 136,618 | 32,550 | 104,068 | 2.00 | Dominance | R$ 570.46 |
| Fortaleza | R$ 16,553,320.00 | R$ 15,750,780.00 | -R$ 802,540.00 | 138,690 | 34,102 | 104,587 | 3.00 | Dominance | R$ 1162.54 |
| Niteroi | R$ 17,344,900.00 | R$ 15,877,620.00 | -R$ 1,467,280.00 | 36,273 | 8924 | 27,350 | 10.00 | Dominance | R$ 2667.28 |
| Belo Horizonte | R$ 25,145,810.00 | R$ 22,258,670.00 | -R$ 2,887,140.00 | 286,541 | 69,796 | 216,745 | 2.50 | Dominance | R$ 3187.14 |
| Campo Grande | R$ 20,438,936.74 | R$ 19,884,587.22 | -R$ 554,349.52 | 101,032 | 25,270 | 75,762 | 5.76 | Dominance | R$ 1245.33 |
| Goiania | R$ 25,256,470.00 | R$ 21,684,930.00 | -R$ 3,571,540.00 | 243,356 | 67,451 | 175,904 | 8.40 | Dominance | R$ 4579.54 |
| Overall (mean) | R$ 20,811,661.37 | R$ 19,394,979.84 | -R$ 1,416,681.53 | 139,857 | 35,248 | 104,609 | 4.61 | Dominance | R$ 1969.94 |
| 20 years horizon | |||||||||
| Manaus | R$ 35,757,671.08 | R$ 35,259,379.55 | -R$ 498,291.54 | 69,081 | 16,406 | 52,675 | 0.46 | Dominance | R$ 553.59 |
| São Paulo | R$ 42,719,776.61 | R$ 42,113,747.62 | -R$ 606,028.99 | 264,432 | 62,923 | 201,509 | 4.47 | Dominance | R$ 1142.53 |
| Fortaleza | R$ 31,782,689.66 | R$ 30,361,540.46 | -R$ 1,421,149.19 | 257,115 | 63,662 | 193,453 | 9.44 | Dominance | R$ 2554.02 |
| Niteroi | R$ 40,937,200.06 | R$ 39,290,941.43 | -R$ 1,646,258.62 | 64,194 | 16,170 | 48,024 | 13.57 | Dominance | R$ 3274.53 |
| Belo Horizonte | R$ 46,235,135.08 | R$ 41,585,954.48 | -R$ 4,649,180.59 | 515,368 | 130,743 | 384,625 | 3.34 | Dominance | R$ 5050.53 |
| Campo Grande | R$ 44,470,163.36 | R$ 40,308,195.96 | -R$ 4,161,967.40 | 184,245 | 47,971 | 136,274 | 8.62 | Dominance | R$ 5196.63 |
| Goiania | R$ 46,928,290.54 | R$ 41,072,988.05 | -R$ 5,855,302.49 | 408,253 | 129,247 | 279,006 | 9.51 | Dominance | R$ 6995.95 |
| Overall (mean) | R$ 41,261,560.91 | R$ 38,570,392.51 | -R$ 2,691,168.40 | 251,813 | 66,732 | 185,081 | 7.06 | Dominance | R$ 3538.25 |
DALY: Disability-adjusted life years; ICER: Incremental cost-effectiveness ratio; NMB: Net monetary benefit (incremental).
a
Reported cases: excluding inapparent infections (asymptomatic and self-care cases).