Table 1.
Modeling equation for the release of VCRS liposomes in PBS containing 2.75%- butanol.
| pH 7.4 | pH 6.5 | pH 5.5 | |
|---|---|---|---|
| Zero-order | Q = 0.51 t + 37.98 (R2 = 0.6634) |
Q = 0.45 t + 44.20 (R2 = 0.7294) |
Q = 0.32 t + 61.38 (R2 = 0.4369) |
| First-order |
Q = 78.42(1-e-0.13t) (R2 = 0.9393) |
Q = 89.01(1-e-0.98t) (R2 = 0.9831) |
Q = 90.63(1-e-0.17t) (R2 = 0.9267) |
| Higuchi | Q = 6.56 t1/2 + 24.13 (R2 = 0.8541) |
Q = 6.00 t1/2 + 31.72 (R2 = 0.8654) |
Q = 4.96 t1/2 + 46.19 (R2 = 0.6704) |
| Ritger-peppas | Q = 26.34 t0.26 (R2 = 0.9298) |
Q = 31.75 t0.23 (R2 = 0.9280) |
Q = 42.27 t0.17 (R2 = 0.8525) |