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ROS: reactive oxygen species, PG-E2: prostaglandin E2
| Targeted periodontal tissue | Reaction of ROS | Effect |
| Ground substance | Depolymerization and degradation (non-sulfated glycosaminoglycans are more susceptible than sulfated) | All these events lead to periodontal tissue destruction and alveolar bone resorption. |
| Collagen | Collagenolysis | |
| Monocytes and macrophages | Stimulation of excessive pro-inflammatory cytokine | |
| Lipid peroxidation | PG-E2 production leads to bone resorption |
