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. 2024 May 21;16(5):e60804. doi: 10.7759/cureus.60804

Table 2. Details of the classification of the selected 27 trials.

Author Year Cancer type Disease status Specific hypothesis Multiple domains (more than one scale or domain included in the analysis) QOL questionnaire If yes, was statistical correction used (multiple domains were independently tested)? Repeated assessments (more than one follow-up assessment included in the analysis) If yes, was a statistical technique used that allowed the inclusion of repeated assessment points, or was a statistical correction used (if repeated assessments were independently tested)? Reporting of descriptive data Primary statistical technique Not reported or unclear (Generalized) linear mixed models, including pattern mixture models Wilcoxon rank-sums test or between-subjects t-test ANOVA or linear regression Time to event Repeated measures ANOVA Proportion of patients or responder analysis Others Reporting of clinical relevance Change of X points (from baseline) X points difference (between arms) Change of X points from baseline and X points differences (between arms) Assessed baseline Compared baseline scores between treatment arms Included baseline as a covariate Intention-to-treat population Baseline compliance rates for each treatment arm Follow-up compliance rates for each treatment arm Strategy to handle missing data
Hagiwara, Y 2018 Pancreas Curative Yes No EQ-5D-3L   Yes Yes Yes Yes No Yes No No No No No No Yes Yes No No Yes Yes Yes No Yes Yes Yes
Kawahara, T 2018 Breast Unresectable No Yes EORTC QLQ-C30, Patient Neurotoxicity Questionnaire No Yes Yes Yes Yes No No No No Yes No No No Yes Yes No No Yes No No No No Yes Yes
Ohashi et, Y 2018 Breast Curative No Yes QOL-ACD, QOL-ACD-B, FACT-ES No Yes Yes Yes Yes No Yes No No No No No No No No No No Yes Yes Yes Yes No No Yes
Yamamoto, D 2017 Breast Unresectable No Yes EORTC-QLQ-C30 No Yes No No No Yes No No No No No No No No No No No Yes No No No Yes Yes No
Shiroiwa, T 2017 Breast Unresectable No No EQ-5D   Yes Yes Yes Yes No Yes No No No No No No Yes Yes No No Yes Yes Yes No Yes Yes Yes
Yoshino, S 2016 Gastric Unresectable No No FACT-Biological Response Modifier   Yes No No No Yes No No No No No No No No No No No Yes No No No Yes No No
Yamazaki, K 2016 Colorectal Unresectable No Yes FACT-C, FACT/GOG-Ntx Not reported or unclear Yes Yes No Yes No No No No No Yes No No No No No No Yes No No Not reported or unclear No No Yes
Nakamura, M 2016 Gastric Curative Yes Yes FACT-Ga, FACT-G Not reported or unclear Yes No Yes No Yes No No No No No No No Yes No No Yes Yes No No Yes Yes Yes Yes
Yokomizo, A 2016 Bladder Curative Not reported or unclear Yes EORTC QLQ-C30 Not reported or unclear No   Yes Yes No No Yes No No No No No No No No No Yes No No No Yes Yes No
Ito, Y 2016 Gastric Curative Yes Yes EORTC-QLQ-C30, STO22 Not reported or unclear Yes No No Yes No No Yes No No No No No Yes No Yes No Yes No No No Yes Yes Yes
Kubota, K 2015 NSCLC Unresectable Not reported or unclear Yes EORTC-QLQ-C30, QLQ-LC13 Not reported or unclear Yes Yes No Yes No No No No No Yes No No No No No No Yes No Yes Not reported or unclear No Yes No
Masuda, K 2015 Rectal Curative Not reported or unclear No Fecal Incontinence Quality of Life   Yes No Yes Yes No No Yes No No No No No No No No No Not reported or unclear     No No No No
Abe, T 2015 NSCLC Unresectable Not reported or unclear No FACT-L   Yes Yes No Yes No No No No No No Yes No No No No No Yes No Yes No Yes Yes Yes
Matsuyama, H 2015 Prostate Curative No Yes Expanded Prostate Cancer Index Composite Not reported or unclear Yes Not reported or unclear No No Yes No No No No No No No No No No No Yes Yes No No No No No
Tsukada, H 2014 NSCLC Unresectable Not reported or unclear No FACT-L   No   Yes Yes No No No Yes No No No No No No No No Yes No Yes Yes Yes Yes No
Sekine, I 2013 SCLC Unresectable Not reported or unclear Yes FACT-L, EQ-5D Not reported or unclear Yes Yes No Yes No No No Yes No No No No No No No No Yes No Yes No Yes Yes No
Ueno, H 2013 Pancreas Unresectable No No EQ-5D   Yes Yes No Yes No No No No No No No Yes No No No No Yes No No Not reported or unclear No No Yes
Shimozuma, K 2012 Breast Curative Yes Yes Patient Neurotoxicity Questionnaire, FACT-G, FACT-Neuro-toxicity Not reported or unclear Yes Yes Yes Yes No No Yes No No No No No No No No No Yes No Yes No Yes Yes Yes
Oizumi, S 2012 NSCLC Unresectable Not reported or unclear No Care Notebook   Yes Yes Yes Yes No No No No Yes No No No Yes Yes No No Yes Yes No No Yes Yes No
Takei, H 2012 Breast Curative Not reported or unclear Yes FACT-B, FACT-ES, CES-D Not reported or unclear Yes Yes No Yes No Yes No No No No No No No No No No Yes No Yes No Yes Yes Yes
Takiguchi, S 2012 Gastric Curative Not reported or unclear Yes EORTC-QLQ-C30, DAUGS 20 Not reported or unclear No   Yes Yes No No Yes No No No No No No No No No No     No No Yes Yes
Ishigami, S 2011 Gastric Curative No No Original   Yes No Yes Yes No No Yes No No No No No No No No No No     No No Yes No
Kawahara, M 2011 NSCLC Unresectable Not reported or unclear Yes FACT-L, FACT-Taxane, FACIT-Sp Not reported or unclear Yes Yes Yes Yes No Yes No No No No No No No No No No Yes Yes Yes No Yes Yes Yes
Shiroiwa, T 2011 Breast Curative No Yes EQ-5D, FACT-G, FACT-B, FACT-Taxane Not reported or unclear Yes Yes Yes Yes No Yes No No No No No No No No No No Yes No Yes Yes No Yes Yes
Ohsumi, S 2011 Breast Curative Not reported or unclear Yes FACT-B, FACT-ES, CES-D Not reported or unclear Yes Yes Yes Yes No No No No No No No Yes No No No No Yes Yes Yes No Yes Yes Yes
Koga, H 2010 Bladder Curative Not reported or unclear Yes EORTC-QLQ-C30 Not reported or unclear Yes No Yes Yes No No No No No No No Yes No No No No Yes No No Not reported or unclear No No No
Takeda, K 2010 NSCLC Unresectable Not reported or unclear No FACT-L   Yes Yes Yes Yes No Yes No No No No No No No No No No Yes No Not reported or unclear Yes Yes Yes Yes