This figure shows the number of publications recorded in PubMed every five years since 1979, along with key discoveries about p53. Due to space constraints, many excellent studies cannot be included here. LFS, Li-Fraumeni syndrome; PTM, post-translational modification; GOF, gain-of-function; NDD, neurodegenerative disease; iPSC, induced pluripotent stem cell; TAD2, transactivation domain 2; KR, lysine-to-arginine mutation.