Table 3.
Effects of Time and Acute Stress on LPA Cluster Expression. LRT indicates likelihood ratio test and is shown when a model including more covariates was a significantly better fit than the reduced model (see Supplemental File S5 for details on model specifications).
| First Principal Component for LPA Cluster | Cluster 5 | Cluster 6 | Cluster 7 | Cluster 8 |
|---|---|---|---|---|
| Estimate (SE) | Estimate (SE) | Estimate (SE) | Estimate (SE) | |
| Fixed effects | ||||
| Intercept | 0.172 (0.40) | −0.217 (0.38) | −0.173 (0.45) | −0.411 (0.41) |
| Session | 0.188 (0.21) | 0.326 (0.25) | 0.332 (0.33) | 0.525 (0.33) |
| Time (30 mins) | −0.020 (0.22) | −0.055 (0.27) | −0.035 (0.22) | 0.333 (0.36) |
| Time (90 mins) | 0.200 (0.37) | 0.415 (0.26) | 0.373 (0.21) † | 0.714 (0.35) * |
| Time (240 mins) | −0.139 (0.22) | 0.107 (0.27) | −0.008 (0.22) | 0.475 (0.35) |
| Interaction: Session x Time (30 mins) | −0.001 (0.28) | −0.036 (0.34) | −0.002 (0.28) | −0.446 (0.45) |
| Interaction: Session x Time (90 mins) | 0.067 (0.27) | −0.162 (0.33) | −0.053 (0.27) | −0.320 (0.44) |
| Interaction: Session x Time (240 mins) | 0.219 (0.26) | 0.151 (0.32) | 0.329 (0.27) | −0.084 (0.43) |
| ELA-status | 0.589 (0.56) | 1.082 (0.50) * | 1.011 (0.62) | 1.124 (0.54) * |
| Interaction: Session x ELA | −0.311 (0.53) | −0.620 (0.36) † | −0.520 (0.48) | −0.612 (0.47) |
| Interaction: ELA x Time (30 mins) | −0.086 (0.33) | −0.180 (0.40) | −0.184 (0.33) | −0.410 (0.54) |
| Interaction: ELA x Time (90 mins) | −0.545 (0.32) † | −0.803 (0.39) * | −0.865 (0.32) ** | −1.329 (0.52) * |
| Interaction: ELA x Time (240 mins) | 0.040 (0.33) | −0.053 (0.41) | 0.000 (0.33) | −0.390 (0.54) |
| Interaction: ELA x Session x Time (30mins) | 0.184 (0.40) | 0.121 (0.50) | 0.113 (0.41) | 0.339 (0.66) |
| Interaction: ELA x Session x Time (90mins) | 0.230 (0.39) | 0.357 (0.48) | 0.385 (0.39) | 0.482 (0.64) |
| Interaction: ELA x Session x Time (240mins) | −0.050 (0.40) | 0.064 (0.49) | −0.147 (0.40) | 0.133 (0.66) |
| Random effects | ||||
| Subject-level Variance | 0.836 (0.92) | 0.705 (0.84) | 1.252 (1.12) | 0.584 (0.76) |
| Session-Intercept Covariance | −0.104 | -- | −0.101 | -- |
| Session | 0.638 (0.80) | -- | 0.448 (0.67) | -- |
| Residual Variance | 0.154 (0.39) | 0.234 (0.48) | 0.156 (0.40) | 0.418 (0.65) |
| AIC/BIC | 334.693/416.691 | 363.882/439.806 | 340.127/422.125 | 423.355/499.280 |
| LRT p-value | P<.001 | -- | P<.001 | −- |
†
P<.10
*
P<.05
**
P<.01.