Table 4.

Effects of Time and Acute Stress on WGCNA Cluster Expression. LRT indicates likelihood ratio test and is shown when a model including more covariates was a significantly better fit than the reduced model (see Supplemental File S6 for details on model specifications).

First Principal Component for WGCNA Cluster	Brown	Blue	Yellow
	Estimate (SE)	Estimate (SE)	Estimate (SE)
Fixed effects
Intercept	0.057 (0.42)	−0.823 (0.43) †	0.621 (0.39)
Session	0.302 (0.42)	0.677 (0.36) †	−0.049 (0.43)
Time (30 mins)	0.174 (0.33)	0.361 (0.39)	−0.115 (0.24)
Time (90 mins)	0.425 (0.32)	0.742 (0.38) †	0.012 (0.23)
Time (240 mins)	0.196 (0.32)	0.423 (0.39)	−0.162 (0.24)
Interaction: Session x Time (30 mins)	−0.157 (0.41)	−0.361 (0.49)	0.151 (0.30)
Interaction: Session x Time (90 mins)	−0.099 (0.40)	−0.402 (0.48)	0.133 (0.29)
Interaction: Session x Time (240 mins)	−0.063 (0.39)	−0.198 (0.47)	0.133 (0.29)
ELA-status	0.827 (0.58)	1.179 (0.56) *	−0.113 (0.53)
Interaction: Session x ELA	−0.290 (0.61)	−0.633 (0.52)	0.371 (0.60)
Interaction: ELA x Time (30 mins)	−0.441 (0.49)	−0.425 (0.59)	−0.120 (0.36)
Interaction: ELA x Time (90 mins)	−1.005 (0.47) *	−1.368 (0.56) *	−0.348 (0.34)
Interaction: ELA x Time (240 mins)	−0.279 (0.50)	−0.275 (0.59)	0.127 (0.36)
Interaction: ELA x Session x Time (30mins)	0.419 (0.60)	0.441 (0.72)	0.088 (0.44)
Interaction: ELA x Session x Time (90mins)	0.389 (0.58)	0.747 (0.69)	0.069 (0.42)
Interaction: ELA x Session x Time (240mins)	0.041 (0.60)	0.152 (0.72)	−0.214 (0.44)
Random effects
Subject-level Variance	0.685 (0.83)	0.568 (0.75)	0.627 (0.79)
Session-Intercept Covariance	−0.129	--	−0.115
Session	0.642 (0.80)	--	1.127 (1.06)
Residual Variance	0.345 (0.59)	0.498 (0.71)	0.183 (0.43)
AIC/BIC	412.995/494.992	442.062/517.985	358.310/440.307
LRT p-value	P<.001	--	P<.001

^†P<.10

^*P<.05

^**P<.01.