Table 2.
Quartile analysis for baseline measures (mean and SD).
| Total | Q1 | Q2 | Q3 | Q4 | p between Q1 and Q4 | |
|---|---|---|---|---|---|---|
|
| ||||||
| Count | 195 | 49 | 48 | 49 | 49 | |
| SEL volume, mm3 | 1123.4 (1451.7) | 101.0 (73.3) | 415.1 (88.5) | 976.9 (277.1) | 3004.0 (1771.9) | <0.001 |
| SEL proportion of T2, % | 6.1 (5.5) | 1.2 (0.7) | 3.3 (0.5) | 6.1 (1.3) | 13.6 (5.6) | <0.001 |
| Age, years | 55.9 (7.0) | 56.0 (6.0) | 57.3 (6.7) | 54.3 (8.3) | 56.2 (6.6) | 0.8a |
| Female, n (%) | 112 (57) | 29 (59) | 22 (46) | 30 (63) | 30 (61) | 0.9b |
| Ibudilast assignment, n (%) | 97 (50) | 27 (55) | 26 (54) | 25 (52) | 19 (39) | 0.2b |
| PPMS, n (%) | 107 (55) | 36 (73) | 27 (56) | 23 (48) | 20 (41) | 0.004b |
| EDSS, median (IQR) | 6.0 (4.0, 6.0) | 5.5 (4.0, 6.0) | 6.0 (4.4, 6.0) | 6.0 (4.0, 6.0) | 6.0 (4.5, 6.5) | 0.037a |
| T25FWT, seconds | 15.0 (18.7) | 11.6 (10.1) | 14.5 (16.5) | 13.9 (18.1) | 20.1 (26.3) | 0.037a |
| 9HPT, seconds | 34.5 (16.3) | 30.8 (11.6) | 35.2 (16.1) | 31.7 (16.2) | 40.5 (19.3) | 0.003a |
| SDMT, #correct | 41.2 (13.4) | 45.2 (12.7) | 41.0 (12.1) | 42.9 (11.9) | 36.1 (15.4) | 0.002a |
| T2LV, mL | 10.3 (10.9) | 1.8 (1.7) | 4.6 (3.5) | 12.6 (7.8) | 22.2 (12.1) | <0.001a |
| T1LV, mL | 3.2 (4.3) | 0.6 (0.8) | 1.1 (1.0) | 4.0 (3.9) | 7.2 (5.6) | <0.001a |
| BPF | 0.804 (0.028) | 0.816 (0.023) | 0.810 (0.025) | 0.798 (0.027) | 0.794 (0.030) | <0.001a |
| GMF | 0.459 (0.019) | 0.464 (0.019) | 0.459 (0.016) | 0.456 (0.018) | 0.457 (0.022) | 0.069a |
| Cortical thickness (mm) | 3.42 (0.21) | 3.55 (0.16) | 3.44 (0.19) | 3.38 (0.21) | 3.30 (0.22) | <0.001a |
| Normalized MTR in normal-appearing brain tissue | 0.279 (0.285) | 0.379 (0.249) | 0.341 (0.328) | 0.215 (0.242) | 0.178 (0.271) | <0.001a |
| Normalized MTR in normal-appearing gray matter | −0.301 (0.282) | −0.207 (0.237) | −0.254 (0.312) | −0.372 (0.270) | −0.375 (0.277) | 0.002a |
| Normalized MTR in whole brain | 0.113 (0.267) | 0.196 (0.235) | 0.174 (0.316) | 0.057 (0.223) | 0.022 (0.250) | 0.001a |
Q1: first quartile; Q2: second quartile; Q3: third quartile; Q4: fourth quartile; PPMS: primary progressive multiple sclerosis; EDSS: Expanded Disability Status Scale; IQR: interquartile range; T25FWT: timed 25-foot walk test; 9HPT: 9-hole peg test; SDMT: symbol digit modalities test; BPF: brain parenchymal fraction; GMF: gray matter fraction; MTR: magnetization transfer ratio; SEL: slowly enlarging lesion; T2LV: T2 lesion volume; T1LV: T1 lesion volume.
a
p values from t-tests.
b
p values from Mann–Whitney U-tests.