Table 3.
Quartile analysis for longitudinal change (mean and SD).
| Total | Q1 | Q2 | Q3 | Q4 | p between Q1 and Q4 | |
|---|---|---|---|---|---|---|
|
| ||||||
| T2LV change, mL | 0.485 (1.600) | 0.197 (0.769) | 0.182 (0.659) | 0.473 (2.308) | 1.098 (1.914) | 0.004a |
| Cumulative new T2 lesion count | 2.82 (8.68) | 0.61 (2.10) | 2.04 (6.12) | 3.48 (7.73) | 5.06 (13.90) | 0.03b |
| T1LV change, mL | 0.341 (0.794) | 0.030 (0.171) | 0.116 (0.249) | 0.398 (0.619) | 0.834 (1.297) | <0.001a |
| New T1 lesion count at week 96 | 1.1 (2.9) | 0.4 (1.6) | 0.8 (2.5) | 1.3 (2.4) | 2.0 (4.3) | 0.42b |
| Annualized change in BPF, per year | −0.001 (0.003) | −0.001 (0.002) | −0.001 (0.004) | −0.001 (0.003) | −0.001 (0.004) | 0.51a |
| Annualized change in cortical thickness, mL/year | −0.007 (0.029) | −0.002 (0.024) | −0.004 (0.031) | −0.011 (0.024) | −0.012 (0.035) | 0.12a |
| T25FWT change, seconds | 3.9 (17.5) | 0.4 (8.1) | 5.0 (15.9) | 0.9 (5.3) | 9.3 (29.0) | 0.04a |
| 9HPT change, seconds | 1.5 (9.0) | 0.8 (9.0) | 0.1 (8.7) | 1.2 (8.4) | 3.8 (9.9) | 0.12a |
| SDMT change, #correct | 0.2 (10.1) | 2.6 (11.4) | 0.7 (11.6) | −1.3 (8.1) | −0.3 (7.0) | 0.15a |
Q1: first quartile; Q2: second quartile; Q3: third quartile; Q4: fourth quartile; BPF: brain parenchymal fraction; T25FWT: timed 25-foot walk test; 9HPT: 9-hole peg test; SDMT: symbol digit modalities test; MTR: magnetization transfer ratio; T2LV: T2 lesion volume; T1LV: T1 lesion volume.
a
p values from t-tests.
b
p values from Mann–Whitney U-tests.