Table 2.

Cerebrospinal fluid proteins with significant group differences between patients and controls, corrected for age, sex, and plate effect.

MMP-10 was significantly upregulated in LDH compared with DDD (q = 0.08), but no other proteins were differently expressed between patient groups (not shown). Values in bold indicate a protein is significantly upregulated/downregulated compared with controls, while color indicates direction: red = upregulation compared with the control group, and blue = downregulation compared with the control group. Full protein names and all analyzed proteins can be found in supplemental file B, available as supplemental digital content at http://links.lww.com/PAIN/B991.

*Protein is upregulated compared with controls in both patient groups. NPX values are given in group means.

coef, regression coefficient; DDD, degenerative disk disease; LDH, lumbar disk herniation; NINS, noninflammatory neurological symptoms; NPX, mean normalized protein expression.