TABLE 1.

Definitions of Types of Cancer Studies

Type of Trial or Study	CoC Terminology	Description
Treatment	Treatment trials	Participants receive specific interventions according to the research plan or protocol. These interventions may be medical products, such as drugs or devices; procedures; or changes to participants' behavior, such as diet.
Biorepository	Cancer-specific biorepositories or tissue banks	Cancer specific-biobanks that collect cancer tissue or blood samples specifically for cancer research purposes
Diagnostic	Diagnostic trials	Examining tests or procedures used to identify or diagnose cancer
Economics	Economics of care related to cancer care	Assesses the costs and effectiveness of cancer interventions and/or analyzes the financial impact of oncology care on patients
Quality-of-life	Quality-of-life or supportive care trials	A broad concept or term used to define observational studies (usually questionnaires or longitudinal studies) that include subjective evaluations of both positive and negative aspects of the patient's life that are affected by the diagnosis and/or treatment of cancer
Genetics	Genetic studies	Studies that examine contributing genes or how different exposures could modify the effect of a gene mutation that may be a risk for cancer development OR genetic assessments that examine genetic polymorphisms and mutations for early risk assessment
Registries	Patient registries	Patient registries with an underlying cancer research focus—epidemiologic studies. Must have underlying cancer research focus, such as National Oncologic PET Registry