TABLE 1.
Categorization of All Family Members in the Research Cohort (189 families) Used as Training Data and the Clinical Cohort (124 families) Used as Validation Data by Sex, No. of Primary Cancers and Mutation Status
| Characteristics | Research Cohort (training data) | Clinical Cohort (validation data) | ||||||
|---|---|---|---|---|---|---|---|---|
| WT | Mut | U | Total | WT | Mut | U | Total | |
| Male, No. | ||||||||
| Healthy | 295 | 9 | 1,276 | 1,580 | 17 | 13 | 1,376 | 1,406 |
| SPC | 105 | 25 | 139 | 269 | 3 | 15 | 210 | 228 |
| MPC | 3 | 14 | 8 | 25 | 1 | 10 | 20 | 31 |
| Subtotal | 403 | 48 | 1,423 | 1,874 | 21 | 38 | 1,606 | 1,665 |
| Female, No. | ||||||||
| Healthy | 341 | 8 | 1,207 | 1,546 | 21 | 20 | 1,203 | 1,244 |
| SPC | 120 | 21 | 102 | 243 | 3 | 33 | 260 | 296 |
| MPC | 4 | 19 | 10 | 33 | 1 | 59 | 32 | 92 |
| Subtotal | 465 | 48 | 1,319 | 1,832 | 25 | 112 | 1,495 | 1,632 |
| Total | 868 | 96 | 2,742 | 3,706 | 46 | 150 | 3,101 | 3,297 |
Abbreviations: MPC, multiple primary cancer; Mut, TP53 mutation; SPC, single primary cancer; U, unknown; WT, wildtype.