Table 3. Mean concentrations (µg/L) of the antimicrobials and other APIs quantified in all water samples (surface and aquifers) in 2016 and 2021.
| Name of the drug | Surface water | Aquifers | ||||
| 2016 | 2021 | Fold change | 2016 | 2021 | Fold change | |
| Average±SD | Average±SD | Average±SD | Average±SD | |||
| Antifungals conc (µg/L) | ||||||
| Fluconazole | 1.06±1.30 | 0.44±0.23 | 0.42 | 13.42±16.53 | 0.13±0.17 | 0.01 |
| Ketoconazole | 0.14±0.06 | 0.03±0.02 | 0.22 | 0.13±0.10 | 0.13±0.22 | 1.03 |
| Itraconazole | 0.02±0.01 | 0.34±0.25 | 21.63 | 0.01±0.01 | 0.22±0.17 | 21.71 |
| Clotrimazole | 0.25±0.13 | 0.02±0.01 | 0.10 | 0.2±0.20 | 0.01±0.01 | 0.02 |
| Miconazole | 1.45±3.59 | 0.03±0.01 | 0.02 | 0.63±0.79 | 0.02±0.01 | 0.03 |
| Terbinafine | 0.13±0.07 | 0±0.00 | 0.02 | 0.75±2.05 | 0.01±0.01 | 0.00 |
| Voriconazole | 0±0.00 | 0.01±0.01 | 2.09 | 0.01±0.00 | 0.01±0.00 | 0.94 |
| Tinidazole | 0±0.00 | 0±0.00 | 0.45 | 0.01±0.01 | 0.01±0.01 | 0.86 |
| Metronidazole | 0.03±0.02 | 0±0.00 | 0.00 | 0.06±0.05 | 0±0.00 | 0.00 |
| Ofloxacin | 1.76±1.84 | 0.18±0.06 | 0.10 | 4.91±7.08 | 0±0.00 | 0.00 |
| Sparfloxacin | 0±0.00 | 0.01±0.00 | NA | 0±0.00 | 0±0.00 | NA |
| Antibacterial (µg/L) | ||||||
| Azithromycin | 0.16±0.13 | 0.09±0.08 | 0.56 | 0.20±0.18 | 0.02±0.01 | 0.08 |
| Norfloxacin | 0.20±0.12 | 0.02±0.02 | 0.12 ↓ | 0.04±0.03 | 0.01±0.00 | 0.31 |
| Ciprofloxacin | 4.88±2.94 | 0.02±0.02 | 0.00 | 6.13±5.23 | 0.01±0.01 | 0.00 |
| Erythromycin | 0.15±0.02 | 0.07±0.02 | 0.49 | 0.08±0.01 | 0.03±0.01 | 0.39 |
| Moxifloxacin | 0.16±0.02 | 0±0.00 | 0.00 | 0.29±0.34 | 0±0.00 | 0.00 |
| Amoxicillin | 0.27±0.18 | 0±0.00 | 0.00 | 0.16±0.21 | 0±0.00 | 0.00 |
| Non-steroidal anti-inflammatory drugs (NSAIDs) (µg/L) | ||||||
| Ibuprofen | 1.36±0.99 | 0.69±0.37 | 0.50 | 0.32±0.16 | 0.54±0.31 | 1.66 |
| Diclofenac | 2.19±4.40 | 0.40±0.21 | 0.18 | 11.87±18.81 | 0.29±0.91 | 0.02 |
| H2 blocker (µg/L) | ||||||
| Cetrizine | 3.49±8.25 | 0.49±0.24 | 0.14 | 2.71±6.60 | 0.01±0.01 | 0.01 |
| Calcium channel blockers (CCBs) (µg/L) | ||||||
| Amlodipine | 0.07±0.07 | 0.01±0.02 | 0.15 | 0.08±0.09 | 0.01±0.01 | 0.10 |
| Aminoglycosides (AG) (µg/L) | ||||||
| Kanamycin | 0.07±0.06 | 0±0.00 | 0.00 | 0.02±0.00 | 0±0.00 | 0.00 |
| Tobramycin | 0.74±0.00 | 4.53±0.15 | 6.17 | 0±0.00 | 4.46±0.13 | NA |
| Streptomycin | 0.35±0.22 | 0±0.00 | 0.00 | 0.25±0.06 | 0±0.00 | 0.00 |
| Amikacin | 0±0.00 | 1.30±0.21 | NA | 0.52±0.00 | 1.18±0.17 | 2.29 |
| Netilmicin | 0.20±0.06 | 0±0.00 | 0.00 | 0.19±0.05 | 0±0.00 | 0.00 |
| Neomycin | 1.18±0.11 | 0±0.00 | 0.00 | 1.05±0.32 | 30.22±9.98 | 28.68 |
| Gentamicin | 0.07±0.05 | 0.20±0.13 | 2.92 | 0.06±0.03 | 0.13±0.13 | 2.25 |