Table 2.
Changes in variables during the treatment period. Numbers indicate the median difference between end and beginning of treatment, presented as % of the values at beginning of treatment
Parameter | huIFN-α2a | AZT | huIFN-α2a/AZT | Placebo | P * |
---|---|---|---|---|---|
Stomatitis | −4.8 | 0.6 | −8.7 | 1.1 | 0.080 |
Haemoglobin (g/dl) | −4.5 | −9.9 | −16.6 | −5.7 | 0.265 |
Haematocrit (%) | −1.0 | −3.1 | −4.9 | −1.6 | 0.703 |
WBC count (cells/µl) | 2.8 | −5.2 | −4.7 | −4.0 | 0.893 |
Relative CD4 count (%) | 3.8 | 2.6 | 4.1 | −4.9 | 0.444 |
Relative CD8 count (%) | −0.8 | −1.6 | 2.4 | 2.2 | 0.443 |
Absolute CD4 count (cells/µl) | −2.0 | −12.3 | 106.2 | 5.6 | 0.335 |
Absolute CD8 count (cells/µl) | −33.0 | −22.5 | 96.7 | 63.7 | 0.089 |
CD4/CD8 ratio | 23.1 | 66.7 | −11.8 | −18.2 | 0.192 |
FeLV p27 antigen | 0.3 | −3.6 | −1.5 | 1.2 | 0.988 |
Comparison between groups by Kruskall–Wallis test
WBC = white blood cell; FeLV = feline leukaemia virus; huIFN-α2a = human interferon-α2a