Table 5. Pre-infusional medication, dosage regimen.

Pre-infusional	Dosage	Route of administration	Recommended interval of administration before amivantamab administration
Antipyretic (required for all doses)	Paracetamol 650 mg to 1000 mg	Intravenous	15 to 30 minutes
		Oral	30 to 60 minutes
Glucocorticoid (required in the initial dose on days 1 and 2 of week 1, optional in subsequent doses)	Dexamethasone 10 mg or methylprednisolone 40 mg	Intravenous	45 to 60 minutes
Antihistamine (required for all doses)	Diphenhydramine 25 mg to 50 mg	Intravenous	15 to 30 minutes
		Oral	30 to 60 minutes