TABLE 3.

The inhibitory actions of compounds 5f, 5h, 5i, 5k, and Novobiocin on E. coli DNA gyrase and topoisomerase IV.

Compound	IC50 (nM) a or RA (%) b	IC50 (µM) a or RA (%) b
	E. Coli DNA gyrase	E. Coli Topo IV
5f	53%	77%
5h	92 ± 5 nM	3.50 ± 0.30 µM
5i	97 ± 6 nM	5.80 ± 0.40 µM
5k	112 ± 7 nM	55%
Novobiocin	170 ± 20 nM	11 ± 2 µM

^a Concentration of compound that inhibits the enzyme activity by 50%.

^b Residual activity of the enzyme at 1 µM of the compound.