TABLE 1.
Recipient, donor, and transplant characteristics at transplantation by the donor age group
| Variable | Donor age group | P | ||
|---|---|---|---|---|
| 45–54 y (N = 446) | 60–69 y (N = 527) | ≥70 y (N = 444) | ||
| Recipient characteristics | ||||
| Age, y | 56 (48–62) | 63 (57–70) | 71 (65–74) | <0.001 |
| Male sex, n (%) | 295 (66) | 348 (66) | 292 (66) | 0.99 |
| Pretransplant history of, n (%) | ||||
| Diabetes | 260 (58) | 290 (55) | 278 (63) | 0.058 |
| Heart disease | 145 (33) | 204 (39) | 193 (44) | 0.003 |
| Vascular disease | 34 (8) | 64 (12) | 56 (13) | 0.028 |
| Treated cancer | 35 (8) | 69 (13) | 93 (21) | <0.001 |
| CMV seropositive | 330 (74) | 400 (76) | 349 (79) | 0.27 |
| Pretransplant | ||||
| Time on dialysis, mo | 22.0 (13.3–35.4) | 24.5 (14.7–39.1) | 23.1 (12.9–34.5) | 0.16 |
| Time on waiting list, mo | 13.8 (7.3–22.2) | 13.6 (7.1–22.3) | 15.0 (7.8–25.8) | 0.10 |
| Mode of first RRT, n (%) | ||||
| Transplantation | 90 (20) | 98 (19) | 96 (22) | 0.50 |
| Hemodialysis | 260 (58) | 324 (61) | 253 (57) | 0.34 |
| Peritoneal dialysis | 96 (22) | 105 (20) | 95 (21) | 0.79 |
| Donor characteristics | ||||
| Age, y | 50 (47–53) | 64 (62–67) | 74 (72–77) | |
| Male sex, n (%) | 254 (57) | 332 (63) | 214 (48) | <0.001 |
| BMI, kg/m2 | 25.6 (23.4–27.8) | 25.7 (23.4–28.3) | 25.1 (23.1–27.8) | 0.13 |
| Last creatinine, mg/dL | 0.77 (0.61–1.00) | 0.76 (0.59–0.99) | 0.74 (0.59–0.90) | 0.077 |
| Cause of death, n (%) | ||||
| Cerebrovascular | 264 (59) | 390 (74) | 393 (89) | <0.001 |
| Other | 182 (41) | 137 (26) | 51 (12) | <0.001 |
| Transplant characteristics, n (%) | ||||
| ≥1 HLA-DR mismatches | 311 (70) | 349 (66) | 318 (72) | 0.18 |
| HLA class I and/or II PRAa | 86 (19) | 100 (19) | 69 (16) | 0.26 |
| Cold ischemia time, h | 13.7 (10.8–17.2) | 13.4 (10.1–17.2) | 12.0 (9.1–15.4) | <0.001 |
Data are presented as median (IQR) or frequencies (%).
aHLA class I and/or II PRA describe the number (%) of patients with PRA ≥20%.
BMI, body mass index; CMV, cytomegalovirus; IQR, interquartile range; PRA, panel-reactive antibody; RRT, renal replacement therapy.