Table 2.

Relative Efficacy and Relative Side Effect Profiles of Pharmacologic Treatment Options for Opioid Use Disorder^76-81

Drug Class	Drug	Relative Efficacy	Relative Side Effect Profile	Abuse Potential	Respiratory Depression Risk	Arrhythmia Risk	Hypotension, Sedation Risk
Partial mu receptor agonist-kappa receptor antagonist	Buprenorphine-naloxone	+++	+	++	++	+	+
Full mu receptor agonist	Methadone	+++	++	+++	+++	++	+
Alpha-2 adrenergic agonist	Clonidine, Lofexidine	++	+++	+	+	+	+++

Note: + indicates relative magnitude on a scale from + to +++.