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. 2024 Jun 17;19:6035–6055. doi: 10.2147/IJN.S459511

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© 2024 Luo et al.

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Fullerenols altered the hippocampus transcriptome in four groups of mice. (A) Hierarchical clustering gene expression heatmap of the four groups of mice. (B) Venn diagram for the treatment of co-regulated DEGs by fullerenols. (C) The top 15 GO pathways in BP enrichment. (D) HUB genes in neurogenesis regulatory pathways. (E) RT-qPCR verification of HUB genes in the regulatory pathways of neurogenesis (Vegfa: genotype effect: F (1, 8) = 8.740, P = 0.0182; drug effect: F (1, 8) = 4.033, P = 0.0795; genotype × drug interaction effect: F (1, 8) = 11.23, P = 0.0101. Sema3a: genotype effect: F (1, 12) = 44.98, P < 0.0001; drug effect: F (1, 12) = 2.494, P = 0.1403; genotype × drug interaction effect: F (1, 12) = 7.387, P = 0.0187. Kdr: genotype effect: F (1, 8) = 70.41, P < 0.0001; drug effect: F (1, 8) = 3.682, P = 0.0913; genotype × drug interaction effect: F (1, 8) = 9.470, P = 0.0152. Flt1: genotype effect: F (1, 12) = 17.61, P = 0.0012; drug effect: F (1, 12) = 7.021, P = 0.0212; genotype × drug interaction effect: F (1, 12) = 9.987, P = 0.0082. Ntrk2: genotype effect: F (1, 8) = 24.72, P = 0.0011; drug effect: F (1, 8) = 13.56, P = 0.0062; genotype × drug interaction effect: F (1, 8) = 11.56, P = 0.0094), the data are presented as mean ± SEM, N = 3–4, *P < 0.05, **P < 0.01, ***P < 0.001.