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. 2024 Jun 21;22(6):e3002666. doi: 10.1371/journal.pbio.3002666

Fig 2. KCNK1 promotes the proliferation, migration, and invasion of breast cancer cells.

Fig 2

(A, B) The overexpression and knockdown efficiencies of KCNK1 were detected by qRT-PCR (A) and western blotting assays (B) in MDA-MB-231 and MCF-7 cells. (C, D) The effect of KCNK1 on the proliferation of MDA-MB-231 and MCF-7 was detected by MTT assays (C) and clone formation assays (D). (E) Wound healing experiments were performed after KCNK1 overexpression or shRNAs knockdown in MDA-MB-231 cells. (F) The effect of KCNK1 on the migration ability of MDA-MB-231 and MCF-7 was detected in transwell experiments without Matrigel. (G) The effect of KCNK1 on the invasion ability of MDA-MB-231 and MCF-7 was detected in transwell experiments with Matrigel. All experiments were triplicated. Data are presented as mean ± SD, analyzed by unpaired two-sided t tests. Source data are provided as S1 Data.