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. 2024 Jun 21;22(6):e3002666. doi: 10.1371/journal.pbio.3002666

Fig 4. KCNK1 promotes the proliferation, migration, and invasion of breast cancer cells via LDHA.

Fig 4

(A, B) The proliferation ability of MDA-MB-231 and MCF-7 cells were detected by MTT assays (A) and clone formation assays (B) after KCNK1 knockdown, LDHA overexpression, or co-transfection of shKCNK1 and LDHA overexpression vectors. (C) Wound healing experiments were performed to detect the migration ability of MDA-MB-231 cells after KCNK1 knockdown, LDHA overexpression, or co-transfection of shKCNK1 and LDHA overexpression vectors. (D) Transwell experiments without Matrigel were performed to detect the migration ability of MDA-MB-231 and MCF-7 cells after KCNK1 knockdown, LDHA overexpression, or co-transfection of shKCNK1 and LDHA overexpression vectors. (E) Transwell experiments with Matrigel were performed to detect the invasion ability of MDA-MB-231 and MCF-7 cells after KCNK1 knockdown, LDHA overexpression, or co-transfection of shKCNK1 and LDHA overexpression vectors. All experiments were triplicated. Data are presented as mean ± SD, analyzed by unpaired two-sided t tests. Source data are provided as S1 Data. LDHA, lactate dehydrogenase A.