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. Author manuscript; available in PMC: 2024 Jun 21.
Published in final edited form as: Biomaterials. 2020 Jun 2;255:120154. doi: 10.1016/j.biomaterials.2020.120154

Figure 3. VML treatment with soluble and tethered agrin constructs increases NMJ formation in vivo.

Figure 3.

A) Cross-sections of explanted muscle stained for myosin heavy chain (MHC; green), neurofilament (β3T; cyan), and acetylcholine receptors (αBTX; red) with dense myotube-positive area and NMJs within the defect area (white dashed line). B) Tethered agrin constructs resulted in more total myofiber area within the defect region than other treatment groups. C) Tethered agrin constructs resulted in more total nerve area in the defect region than other treatment groups. D) Both soluble and tethered agrin constructs resulted in higher percentages of AChR clusters within an NMJ than no agrin controls. *: p < 0.05; **: p < 0.01