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m6A and m5C can act as opposing regulatory marks during biological processes, such as the maternal-to-zygotic transition. While m6A destabilizes maternal mRNAs via recruitment of mRNA decay machinery, m5C protects a subset of maternal transcripts from premature degradation by recruiting YBX1 and PABPC1. Abbreviations: m5C, N5-methylcytidine; m6A, N6-methyladenosine.
