Table 2.

In vivo biodistribution results of [¹⁸F]F-PSMA-617-NODA ([¹⁸F]1) and [¹⁸F]F-PSMA-617-RESCA ([¹⁸F]2) derivatives

Tissue (SUV mean)	[18F]F-PSMA-617-NODA ([18F]1) (n = 3)			[18F]F-PSMA-617-RESCA ([18F]2) (n = 3)
	10’	60’	120’	10’	60’	120’
Muscle	0.14 ± 0.01	0.07 ± 0.01	0.03 ± 0.01	0.19 ± 0.05	0.12 ± 0.02	0.11 ± 0.04
Heart	0.26 ± 0.05	0.10 ± 0.03	0.04 ± 0.002§	0.35 ± 0.05	0.17 ± 0.03	0.11 ± 0.03
Liver	0.22 ± 0.01§	0.11 ± 0.01	0.05 ± 0.01	0.98 ± 0.15	0.65 ± 0.22	0.30 ± 0.11
Kidney	13.11 ± 1.60§	13.32 ± 2.23	9.30 ± 3.60	6.92 ± 1.16	10.21 ± 0.80	10.64 ± 1.25
Salivary gland	0.54 ± 0.17	0.24 ± 0.09§	0.08 ± 0.04§	0.54 ± 0.14	0.45 ± 0.10	0.28 ± 0.10
Lung	0.20 ± 0.04	0.09 ± 0.04§	0.04 ± 0.01§	0.31 ± 0.01	0.19 ± 0.04	0.12 ± 0.03
Small instestine	0.32 ± 0.05	0.25 ± 0.06§	0.15 ± 0.06§	1.99 ± 1.44	3.07 ± 1.02	5.79 ± 2.07
Colon	0.37 ± 0.08	0.27 ± 0.13	0.16 ± 0.03	0.29 ± 0.23	0.78 ± 1.05	3.87 ± 5.37
Bone	0.18 ± 0.09	0.13 ± 0.08	0.12 ± 0.09	0.21 ± 0.03	0.20 ± 0.07	0.15 ± 0.11
Gall bladder	0.33 ± 0.11	0.10 ± 0.03	0.04 ± 0.01	3.28 ± 3.18	5.22 ± 4.23	5.07 ± 4.26
Brain	0.06 ± 0.01	0.03 ± 0.01§	0.02 ± 0.01§	0.09 ± 0.02	0.07 ± 0.02	0.07 ± 0.01

^§p versus [¹⁸F]PSMA-617-RESCA

Data are reported as SUV mean of respective regions of interest. Average values ± SD (§, p < 0.05 by unpaired t test) were calculated per group at 10, 60 and 120 min